TN, NMF, WH, and SA wrote the software. NMF, SB, SFunk, ACG, DDA, and AMP acquired funding. provided as a service to MMWR readers and do not constitute or imply Coinciding with Omicron variant predominance, COVID-19associated hospitalization rates among adults increased in late December 2021 and peaked in January 2022; rates increased more among Black adults relative to rates among adults of other racial and ethnic groups. * Data are from a weighted sample of hospitalized nonpregnant adults with completed medical record abstractions and a discharge disposition. Baxter, R., Bartlett. The company also said full results of its 2,250-person study confirmed the pill's promising early results against the virus: The drug reduced combined hospitalizations and deaths by about 89. The development of a standardized neighborhood deprivation index. Among children 12 to 17, the . Sarah J. PubMed Rep. 69, 10811088 (2020). Monthly COVID-19 hospitalization rates were 3.5 to 17.7 times higher in unvaccinated patients than in their vaccinated counterparts, regardless of whether they had received a booster. Members receive almost all their medical care at KPNC-owned facilities, including clinics, hospitals, pharmacies, and laboratories. Rep. 70, 895899 (2021). Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. For infants, we included age, as a categorical time-changing variable in 30-day increments. Klein, N. P. et al. wrote the initial manuscript. Wkly. Data from the COVID-19Associated Hospitalization Surveillance Network (COVID-NET) were analyzed to compare COVID-19associated hospitalization rates among adults aged 18 years during B.1.617.2 (Delta; July 1December 18, 2021) and Omicron (December 19, 2021January 31, 2022) variant predominance, overall and by race/ethnicity and vaccination status. We thank staff at UKHSA and members of the UK Government SPI-M committee and the UKHSA Variant Technical Group for valuable discussions. Morb. During the proxy omicron period, we found a vaccine effectiveness of 70% (95% confidence interval . * Adults who completed a primary vaccination series were defined as those who had received the second dose of a 2-dose primary vaccination series or a single dose of a 1-dose product 14 days before a positive SARS-CoV-2 test associated with their hospitalization but received no booster dose. Study finds Omicron hospital risk 10 times higher in unvaccinated COVID hospitalizations amid omicron 23 times higher among - ABC News JAMA Netw. PubMed These findings are consistent with the diminishing of pregnancy-derived antibodies in infants over time22. COVID-19associated signs and symptoms included respiratory symptoms (congestion or runny nose, cough, hemoptysis or bloody sputum, shortness of breath or respiratory distress, sore throat, upper respiratory infection, influenza-like illness, and wheezing) and non-respiratory symptoms (abdominal pain, altered mental status or confusion, anosmia or decreased smell, chest pain, conjunctivitis, diarrhea, dysgeusia or decreased taste, fatigue, fever or chills, headache, muscle aches or myalgias, nausea or vomiting, rash, and seizures). The data cannot be shared publicly because the data contain potentially identifying or sensitive patient information and is legally restricted by Kaiser Permanente Northern California. J. Just 28% of children in the age group - around 8 million . In addition, our study period included two different SARV-CoV-2 variants, which allowed estimation of the effectiveness of vaccination during pregnancy in infants during both the Delta and Omicron variant periods. They help us to know which pages are the most and least popular and see how visitors move around the site. We further classified vaccination status by the trimester within which the second dose or the unique dose (for those who received only one dose) was received. However, linking is sometimes not possible because CDC does not receive personally identifiable information about vaccine doses. Adults who received booster doses were classified as those who completed their primary vaccination series and received an additional or booster dose of vaccine on or after August 13, 2021, at any time after the completion of their primary series, and 14 days before a positive test result for SARS-CoV-2, because COVID-19associated hospitalizations are a lagging indicator, and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). Risk factors for severe COVID-19 in children. J. Med. All adults should stay up to date with COVID-19 vaccination to reduce their risk for COVID-19associated hospitalization. During the Omicron-predominant period, overall weekly adult hospitalization rates peaked at 38.4 per 100,000, exceeding the previous peak on January 9, 2021 (26.1) and the peak rate during the Delta-predominant period (15.5) (Figure 1). Hospitalisation associated with SARS-CoV-2 delta variant in Denmark. Pediatr. Surveillance officers abstracted data on sampled patients from medical charts. It is critical that nursing home residents stay up to date with CO VID-19 vaccines and receive a bivalent booster dose to maximize protection against COVID-19. While this proportion might not be representative of the proportion of vaccinated pregnant women within KPNC because of our exclusion criteria, more efforts are needed to promote COVID-19 vaccines for pregnant persons because vaccination provides protection to mothers and their infants until they are old enough to receive their own COVID-19 vaccines. Accessed March 10, 2022. COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19associated hospitalizations in 99 counties across 14 states. COVID-19associated hospitalizations are those occurring among residents of a predefined surveillance catchment area who have a positive real-time reverse transcriptionpolymerase chain reaction (RT-PCR) or rapid antigen detection test result for SARS-CoV-2 during hospitalization or the 14 days preceding admission. #FridayNight | #FridayNight | By Citizen TV Kenya | Facebook | Good SARS-CoV-2 delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. T.R. Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. Hospitalization of infants and children aged 0-4 years with laboratory-confirmed COVID-19COVID-NET, 14 states, March 2020-February 2022. The difference between the two studies might be due to population characteristics and the timing of follow-up as ours went through May 31, 2022, while the Norwegian study ended in April 2022. COVID-19 vaccination during pregnancy: coverage and safety. U.S. regulators had authorized the Pfizer/BioNTech COVID-19 vaccine for children aged 5 to 11 years in October, prior to the Omicron surge. The code used to analyse the data is available on. Published by Elsevier Ltd. Gordon, N. & Lin, T. The Kaiser Permanente Northern California adult member health survey. 241(d); 5 U.S.C. Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. Percentages presented for the overall number are weighted row percentages. Google Scholar. TN, NMF, SFlax, MC, DDA, AMP, and ST conceptualised the work. https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1 Zerbo, O., Ray, G.T., Fireman, B. et al. All adults should stay up to date (1) with COVID-19 vaccination to reduce their risk for COVID-19associated hospitalization. Shimabukuro, T. T. et al. IMV status was missing in 1.4% (weighted) of hospitalizations; these hospitalizations are otherwise included elsewhere in the analysis. N. Engl. Hospitalization rates were 10.5 times higher in the unvaccinated and 2.5 times higher in vaccinated patients with no booster than in booster recipients. Effectiveness of BNT162b2 vaccination during pregnancy in preventing hospitalization for SARS-CoV-2 in infants. National influenza and COVID-19 surveillance report: 27 January 2022 (week 4). All information these cookies collect is aggregated and therefore anonymous. https://www.cdc.gov/mmwr/volumes/70/wr/mm7050e2.htm, Adults who completed their primary COVID-19 vaccination series were defined as those who had received the second dose of a 2-dose primary vaccination series or a single dose of a 1-dose primary vaccine product 14 days before receipt of a positive SARS-CoV-2 test result associated with their hospitalization but received no additional or booster dose. Vaccinations were limited only to those received during pregnancy. However, infants aged <6 months are not currently eligible for any currently available COVID-19 vaccines and must rely on placentally acquired immunity from their mothers. 189, 13791388 (2020). Most QCovid risk groups were tied to an increased risk of post-booster death, except congenital heart disease, asthma, and previous fracture. Models were adjusted for the covariates listed above. Frequency, characteristics and complications of COVID-19 in hospitalized infants. First, COVID-19associated hospitalizations might have been missed because of hospital testing practices and test availability. Laurie M. Billing and Kenzie Teno report grants from the Council of State and Territorial Epidemiologists during the conduct of the study. Mortal. Adults with no documented receipt of any COVID-19 vaccine dose before the test date were considered unvaccinated. Vaccine effectiveness of cell-culture relative to egg-based inactivated influenza vaccine during the 2017-18 influenza season. Omicron Is Not More Severe for Children, Despite Rising Hospitalizations More children are being treated for Covid, but a combination of factors, including low vaccination rates, most. Omicron vaccine effectiveness estimates for 7 to 59 days, 60 to 119 days, and 240 days or more after the second dose are not presented owing to imprecision in the estimates and wide 95% CIs (ie, 100 percentage points). Zerbo, O. et al. Rep. 71, 429436 (2022). Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. Morb. Comparative analysis of the risks of hospitalisation and death 384, 403416 (2021). BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting. Graff, K. et al. Starting the week ending December 4, 2021, Maryland data are not included in calculations but are included in previous weeks. Two new observational studies suggest that COVID-19 vaccination lowers long-COVID incidence and severity. J. Pediatr. Morb. But the charts are in line with data from the UK Health Safety Agency, which found that protection from a third dose of Pfizer or Moderna vaccine against hospitalization with Omicron was about 89%, waning slightly to 83% at 10 weeks, Insider's Catherine Schuster Bruce reported. Wkly. RESP-NET: COVID-19 Associated Hospitalization Rates among Adults Ages 65 Years and Older CDC's Respiratory Virus Hospitalization Surveillance Network (RESP-NET) shows that overall weekly rates of COVID-19-associated hospitalizations have declined for all age groups from a peak in December 2022. https://doi.org/10.1038/s41467-023-36547-4, DOI: https://doi.org/10.1038/s41467-023-36547-4. Persons with multiple, unknown, or missing race accounted for 6.9% (weighted) of all cases. Our analysis . The finding that maternal vaccination was less effective at protecting infants during the Omicron dominant period is also consistent with previous studies which have reported decreased effectiveness of mRNA COVID-19 vaccines during Omicron among children and adults14,20. Child hospitalization rates reach record highs amid Omicron's surge Over the entire study period, the crude rate of hospitalization with a SARS-CoV-2 positive test was lower during the first 6 months of life among infants whose mothers received at least two doses . Vaccination status is based on state immunization information system data. ; COVID-NET Surveillance Team. Like influenza and Tdap vaccines15,16, data suggest that vaccination during pregnancy may protect infants who are not old enough to be vaccinated against COVID-19. If SARS-CoV-2 test date was missing, hospitalization admission date was used. VE against hospitalization was not estimated because of the very small number of hospitalized cases. Blakeway, H. et al. Partially vaccinated adults, and those who received a single dose of a 1-dose product <14 days before the positive SARS-CoV-2 test result were not included in analyses by vaccination status but were included in rates and overall proportions that were not stratified by vaccination status. SARS-CoV-2 infections can result in COVID-19associated hospitalizations, even among vaccinated persons.
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